Dr Austin Kulasekararaj

Consultant Haematologist

Year Qualified: 1998
Qualifications: MBBS MD MRCP FRCPath
Specialty: Haematology

Special Interests

Acute leukaemia
Allogeneic stem cell transplantation
Aplastic anaemia
Myelodysplastic syndromes (MDS)
Paroxysmal nocturnal hemoglobinuria (PNH)

Biography

I have trained and worked in King’s since 2004, undertaking research in molecular pathogenesis of MDS and aplastic anaemia. I specialise in bone marrow failures, myeloid malignancies and allogeneic bone marrow transplantation. I also lead the King’s PNH Centre, which is one of two NHS England-commissioned highly specialised services for PNH.

Related services

Haematology

Research

Benson-Quarm N, Gandhi S, Kulasekararaj A, Marsh J (2014) ‘Aplastic anaemia‘, Hematology (Amsterdam, Netherlands), 19,(1):60-1
Kulasekararaj AG, Jiang J, Smith AE, Mohamedali AM, Mian S, Gandhi S, Gaken J, Czepulkowski B, Marsh JC, Mufti GJ (2014) ‘Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome‘, Blood, 124,(17):2698-704
Saft L, Karimi M, Ghaderi M, Matolcsy A, Mufti GJ, Kulasekararaj A, Göhring G, Giagounidis A, Selleslag D, Muus P, Sanz G, Mittelman M, Bowen D, Porwit A, Fu T, Backstrom J, Fenaux P, MacBeth KJ, Hellström-Lindberg E (2014) ‘p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)‘, Haematologica, 99,(6):1041-9
Bart-Smith EE, Kordasti S, Kulasekararaj AG, Richardson D, Mufti GJ, Marsh JC (2014) ‘Successful treatment of aplastic anaemia associated with HIV infection with eltrombopag: implications for a possible immunomodulatory role‘, AIDS (London, England), 28,(18):2786-8
Dufour C, Pillon M, Passweg J, Socié G, Bacigalupo A, Franceschetto G, Carraro E, Oneto R, Risitano AM, Peffault de Latour R, Tichelli A, Rovo A, Peters C, Hoechsmann B, Samarasinghe S, Kulasekararaj AG, Schrezenmeier H, Aljurf M, Marsh J (2014) ‘Outcome of aplastic anemia in adolescence: a survey of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation‘, Haematologica, 99,(10):1574-81
Clay J, Kulasekararaj AG, Potter V, Grimaldi F, McLornan D, Raj K, de Lavallade H, Kenyon M, Pagliuca A, Mufti GJ, Marsh JC (2014) ‘Nonmyeloablative peripheral blood haploidentical stem cell transplantation for refractory severe aplastic anemia‘, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20,(11):1711-6
Marsh JC, Kulasekararaj AG (2013) ‘Management of the refractory aplastic anemia patient: what are the options?‘, Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 2013,():87-94
Gandhi S, Kulasekararaj AG, Mufti GJ, Marsh JC (2013) ‘Allogeneic stem cell transplantation using alemtuzumab-containing regimens in severe aplastic anemia‘, International journal of hematology, 97,(5):573-80
Young ME, Potter V, Kulasekararaj AG, Mufti GJ, Marsh JC (2013) ‘Haematopoietic stem cell transplantation for acquired aplastic anaemia‘, Current opinion in hematology, 20,(6):515-20
Kulasekararaj AG, Mohamedali AM, Mufti GJ (2013) ‘Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes‘, British journal of haematology, 162,(5):587-605
Costantini B, Kordasti SY, Kulasekararaj AG, Jiang J, Seidl T, Abellan PP, Mohamedali A, Thomas NS, Farzaneh F, Mufti GJ (2013) ‘The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome‘, Haematologica, 98,(8):1196-205
Kulasekararaj AG, Smith AE, Mian SA, Mohamedali AM, Krishnamurthy P, Lea NC, Gäken J, Pennaneach C, Ireland R, Czepulkowski B, Pomplun S, Marsh JC, Mufti GJ (2013) ‘TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis‘, British journal of haematology, 160,(5):660-72
Mohamedali AM, Alkhatabi H, Kulasekararaj A, Shinde S, Mian S, Malik F, Smith AE, Gäken J, Mufti GJ (2013) ‘Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome‘, Blood, 122,(4):567-70
Mian SA, Smith AE, Kulasekararaj AG, Kizilors A, Mohamedali AM, Lea NC, Mitsopoulos K, Ford K, Nasser E, Seidl T, Mufti GJ (2013) ‘Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome‘, Haematologica, 98,(7):1058-66
Krishnamurthy P, Potter VT, Barber LD, Kulasekararaj AG, Lim ZY, Pearce RM, de Lavallade H, Kenyon M, Ireland RM, Marsh JC, Devereux S, Pagliuca A, Mufti GJ (2013) ‘Outcome of donor lymphocyte infusion after T cell-depleted allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndromes‘, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19,(4):562-8
Marsh JC, Kulasekararaj AG (2013) ‘Management of the refractory aplastic anemia patient: what are the options?‘, Blood, 122,(22):3561-7
Gaymes TJ, Mohamedali AM, Patterson M, Matto N, Smith A, Kulasekararaj A, Chelliah R, Curtin N, Farzaneh F, Shall S, Mufti GJ (2013) ‘Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies‘, Haematologica, 98,(9):1397-406
Giagounidis AA, Kulasekararaj A, Germing U, Radkowski R, Haase S, Petersen P, Göhring G, Büsche G, Aul C, Mufti GJ, Platzbecker U (2012) ‘Long-term transfusion independence in del(5q) MDS patients who discontinue lenalidomide‘, Leukemia, 26,(4):855-8
Kordasti S, Marsh J, Al-Khan S, Jiang J, Smith A, Mohamedali A, Abellan PP, Veen C, Costantini B, Kulasekararaj AG, Benson-Quarm N, Seidl T, Mian SA, Farzaneh F, Mufti GJ (2012) ‘Functional characterization of CD4+ T cells in aplastic anemia‘, Blood, 119,(9):2033-43
Kulasekararaj AG, Mufti GJ (2012) ‘The non-transplant treatment of myelodysplastic syndromes-what’s on the horizon?‘, Seminars in hematology, 49,(4):350-60
Gäken J, Mohamedali AM, Jiang J, Malik F, Stangl D, Smith AE, Chronis C, Kulasekararaj AG, Thomas NS, Farzaneh F, Tavassoli M, Mufti GJ (2012) ‘A functional assay for microRNA target identification and validation‘, Nucleic acids research, 40,(10):e75
Bullenkamp J, Cole D, Malik F, Alkhatabi H, Kulasekararaj A, Odell EW, Farzaneh F, Gäken J, Tavassoli M (2012) ‘Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin‘, Cell death & disease, 3,():e296
Zeisig BB, Kulasekararaj AG, Mufti GJ, So CW (2012) ‘SnapShot: Acute myeloid leukemia‘, Cancer cell, 22,(5):698-698.e1
Tiu RV, Gondek LP, O’Keefe CL, Elson P, Huh J, Mohamedali A, Kulasekararaj A, Advani AS, Paquette R, List AF, Sekeres MA, McDevitt MA, Mufti GJ, Maciejewski JP (2011) ‘Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies‘, Blood, 117,(17):4552-60
Jädersten M, Saft L, Smith A, Kulasekararaj A, Pomplun S, Göhring G, Hedlund A, Hast R, Schlegelberger B, Porwit A, Hellström-Lindberg E, Mufti GJ (2011) ‘TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression‘, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29,(15):1971-9
Bartram JL, O’Driscoll S, Kulasekararaj AG, Height SE, Dick M, Patel S, Rees DC (2011) ‘Portacaths are safe for long-term regular blood transfusion in children with sickle cell anaemia‘, Archives of disease in childhood, 96,(11):1082-4
Smith AE, Mohamedali AM, Kulasekararaj A, Lim Z, Gäken J, Lea NC, Przychodzen B, Mian SA, Nasser EE, Shooter C, Westwood NB, Strupp C, Gattermann N, Maciejewski JP, Germing U, Mufti GJ (2010) ‘Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value‘, Blood, 116,(19):3923-32