Dr Mohammad Ibrahim

Consultant Immunologist / Clinical Lead

Year Qualified: 1982
Qualifications: MBBCh, MSc, PhD, FRCPath, FRCP, FAAAAI
Specialty: Immunology

Special Interests

Allergy
Primal immunodeficiency

Biography

Dr Ibrahim trained as a physician and scientist in Immunology at University College London and Imperial College Schools of Medicine, before joining King’s in 2001. Since then he has created two new outpatient-based clinical allergy and primary immunodeficiency (PID) services for adults. The PID service sees patients from across south east England. He is Director of King’s Health Partners (KHP) Diagnostic Immunology Laboratory and has overseen expansion and improvements since taking up this role in 2004.

Dr Ibrahim’s strategic programme of research aims to use his knowledge of immunology and dendritic cells to design rational and novel immunotherapies. His clinical and scientific expertise is recognised nationally and internationally – he has lectured and delivered research presentations internationally, and he reviews submissions to journals and grants for national and international bodies.

Related services

Allergy and immunology

Research

Waheed A, Dalton B, Wesemann U, Ibrahim MAA, Himmerich H (2018) ‘A Systematic Review of Interleukin-1ß in Post-Traumatic Stress Disorder: Evidence from Human and Animal Studies‘, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 38,(1):1-11
Dalton B, Bartholdy S, Robinson L, Solmi M, Ibrahim MAA, Breen G, Schmidt U, Himmerich H (2018) ‘A meta-analysis of cytokine concentrations in eating disorders‘, Journal of psychiatric research, 103,():252-264
Dalton B, Whitmore V, Patsalos O, Ibrahim MAA, Schmidt U, Himmerich H (2018) ‘A systematic review of in vitro cytokine production in eating disorders‘, Molecular and cellular endocrinology, ():
Coulter TI, Chandra A, Bacon CM, Babar J, Curtis J, Screaton N, Goodlad JR, Farmer G, Steele CL, Leahy TR, Doffinger R, Baxendale H, Bernatoniene J, Edgar JD, Longhurst HJ, Ehl S, Speckmann C, Grimbacher B, Sediva A, Milota T, Faust SN, Williams AP, Hayman G, Kucuk ZY, Hague R, French P, Brooker R, Forsyth P, Herriot R, Cancrini C, Palma P, Ariganello P, Conlon N, Feighery C, Gavin PJ, Jones A, Imai K, Ibrahim MA, Markelj G, Abinun M, Rieux-Laucat F, Latour S, Pellier I, Fischer A, Touzot F, Casanova JL, Durandy A, Burns SO, Savic S, Kumararatne DS, Moshous D, Kracker S, Vanhaesebroeck B, Okkenhaug K, Picard C, Nejentsev S, Condliffe AM, Cant AJ (2017) ‘Clinical spectrum and features of activated phosphoinositide 3-kinase d syndrome: A large patient cohort study‘, The Journal of allergy and clinical immunology, 139,(2):597-606.e4
Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G (2017) ‘Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection‘, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 17,(4):931-943
Hussein S, Dalton B, Willmund GD, Ibrahim MAA, Himmerich H (2017) ‘A Systematic Review of Tumor Necrosis Factor-a in Post-Traumatic Stress Disorder: Evidence from Human and Animal Studies‘, Psychiatria Danubina, 29,(4):407-420
Dobbs SM, Dobbs RJ, Weller C, Charlett A, Augustin A, Taylor D, Ibrahim MA, Bjarnason I (2016) ‘Peripheral aetiopathogenic drivers and mediators of Parkinson’s disease and co-morbidities: role of gastrointestinal microbiota‘, Journal of neurovirology, 22,(1):22-32
Kracker S, Curtis J, Ibrahim MA, Sediva A, Salisbury J, Campr V, Debré M, Edgar JD, Imai K, Picard C, Casanova JL, Fischer A, Nejentsev S, Durandy A (2014) ‘Occurrence of B-cell lymphomas in patients with activated phosphoinositide 3-kinase d syndrome‘, The Journal of allergy and clinical immunology, 134,(1):233-6
Makatsori M, Kiani-Alikhan S, Manson AL, Verma N, Leandro M, Gurugama NP, Longhurst HJ, Grigoriadou S, Buckland M, Kanfer E, Hanson S, Ibrahim MA, Grimbacher B, Chee R, Seneviratne SL (2014) ‘Hypogammaglobulinaemia after rituximab treatment-incidence and outcomes‘, QJM : monthly journal of the Association of Physicians, 107,(10):821-8
Liu Y, Hanson S, Gurugama P, Jones A, Clark B, Ibrahim MA (2014) ‘Novel NFKB2 mutation in early-onset CVID‘, Journal of clinical immunology, 34,(6):686-90
Kiani-Alikhan S, Yong PF, Grosse-Kreul D, Elston C, Ibrahim MA (2012) ‘Immunoglobulin replacement therapy: is there a role for IgA and IgM?‘, The Journal of allergy and clinical immunology, 130,(2):553-4; author reply 554
Kiani-Alikhan S, Yong PF, Gilmour KC, Grosse-Kreul D, Davies EG, Ibrahim MA (2012) ‘Phenotypic heterogeneity in a family with a CD40 ligand intracellular domain mutation‘, Journal of clinical immunology, 32,(1):70-7
Dobbs RJ, Charlett A, Dobbs SM, Weller C, A Ibrahim MA, Iguodala O, Smee C, Plant JM, Lawson AJ, Taylor D, Bjarnason I (2012) ‘Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study‘, Gut pathogens, 4,(1):12
Kiani-Alikhan S, Yong PF, Grosse-Kreul D, Height SE, Mijovic A, Suddle AR, Ibrahim MA (2010) ‘Successful desensitization to immunoglobulin A in a case of transfusion-related anaphylaxis‘, Transfusion, 50,(9):1897-901
Dobbs SM, Dobbs RJ, Weller C, Charlett A, Bjarnason IT, Lawson AJ, Letley D, Harbin L, Price AB, Ibrahim MA, Oxlade NL, Bowthorpe J, Leckstroem D, Smee C, Plant JM, Peterson DW (2010) ‘Differential effect of Helicobacter pylori eradication on time-trends in brady/hypokinesia and rigidity in idiopathic parkinsonism‘, Helicobacter, 15,(4):279-94
Charlett A, Dobbs RJ, Dobbs SM, Weller C, Ibrahim MA, Dew T, Sherwood R, Oxlade NL, Plant JM, Bowthorpe J, Lawson AJ, Curry A, Peterson DW, Bjarnason IT (2009) ‘Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established disease‘, Gut pathogens, 1,(1):20
Yong PF, Malik R, Arif S, Peakman M, Amiel S, Ibrahim MA, Gough A (2009) ‘Rituximab and omalizumab in severe, refractory insulin allergy‘, The New England journal of medicine, 360,(10):1045-7
Hamlyn E, Ibrahim MA, Post FA (2008) ‘Resolution of HIV-associated adult lymphocytic interstitial pneumonitis in pregnancy‘, AIDS (London, England), 22,(10):1244-5
Dobbs RJ, Dobbs SM, Weller C, Charlett A, Bjarnason IT, Curry A, Ellis DS, Ibrahim MA, McCrossan MV, O’Donohue J, Owen RJ, Oxlade NL, Price AB, Sanderson JD, Sudhanva M, Williams J (2008) ‘Helicobacter hypothesis for idiopathic parkinsonism: before and beyond‘, Helicobacter, 13,(5):309-22
Yong PF, Workman S, Wahid F, Exley A, Webster AD, Ibrahim MA (2008) ‘Selective deficits in blood dendritic cell subsets in common variable immunodeficiency and X-linked agammaglobulinaemia but not specific polysaccharide antibody deficiency‘, Clinical immunology (Orlando, Fla.), 127,(1):34-42
Bachy V, Williams DJ, Ibrahim MA (2008) ‘Altered dendritic cell function in normal pregnancy‘, Journal of reproductive immunology, 78,(1):11-21
Yong PF, Post FA, Gilmour KC, Grosse-Kreul D, King A, Easterbrook P, Ibrahim MA (2008) ‘Cerebral toxoplasmosis in a middle-aged man as first presentation of primary immunodeficiency due to a hypomorphic mutation in the CD40 ligand gene‘, Journal of clinical pathology, 61,(11):1220-2
Yong PF, Li H, Chung-Faye G, Ibrahim MA (2008) ‘Collagenous colitis in a patient with common variable immunodeficiency‘, Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologia, 18,(6):482-3
Yong PF, Grosse-Kreul D, Maher J, Salisbury JR, Ibrahim MA (2007) ‘Dermatofibrosarcoma protuberans in a patient with X-linked agammaglobulinaemia‘, Journal of clinical pathology, 60,(10):1162-4
Lo AS, Gorak-Stolinska P, Bachy V, Ibrahim MA, Kemeny DM, Maher J (2007) ‘Modulation of dendritic cell differentiation by colony-stimulating factor-1: role of phosphatidylinositol 3′-kinase and delayed caspase activation‘, Journal of leukocyte biology, 82,(6):1446-54
Yong PF, Birns J, Ibrahim MA (2007) ‘Anaphylactic shock: the great mimic‘, Southern medical journal, 100,(3):295-7
Yong PF, Grosse-Kreul D, Devereux S, Pagliuca A, Maher J, Ibrahim MA (2006) ‘Increase in allergy following donor lymphocyte infusions‘, Bone marrow transplantation, 37,(10):983-4
Kandil H, Bachy V, Williams DJ, Helmi R, Gotch FM, Ibrahim MA (2005) ‘Regulation of dendritic cell interleukin-12 secretion by tumour cell necrosis‘, Clinical and experimental immunology, 140,(1):54-64
Lambert C, Ibrahim M, Iobagiu C, Genin C (2005) ‘Significance of unconventional peripheral CD4+CD8dim T cell subsets‘, Journal of clinical immunology, 25,(5):418-27
Lea NC, Orr SJ, Stoeber K, Williams GH, Lam EW, Ibrahim MA, Mufti GJ, Thomas NS (2003) ‘Commitment point during G0–>G1 that controls entry into the cell cycle‘, Molecular and cellular biology, 23,(7):2351-61
Sidwell RU, Ibrahim MA, Bunker CB (2002) ‘A case of common variable immunodeficiency presenting with furunculosis‘, The British journal of dermatology, 147,(2):364-7
Ibrahim MA, Gotch FM (2000) ‘Making smarter immunotherapies‘, Nature immunology, 1,(1):3
Ibrahim MA, Chain BM, Katz DR (1995) ‘The injured cell: the role of the dendritic cell system as a sentinel receptor pathway‘, Immunology today, 16,(4):181-6
Ibrahim MA, Chain BM, Katz DR (1994) ‘The role of non-adhesive T-cell-accessory cell interactions in the induction of T-cell proliferative hyporesponsiveness‘, Immunology, 81,(4):521-31
Ellis J, Ibrahim MA, Chain BM, Katz DR (1993) ‘The role of dendritic cells in the regulation of T cell cytokine synthesis‘, Advances in experimental medicine and biology, 329,():99-104
King PD, Ibrahim MA, Katz DR (1993) ‘Adhesion molecules: co-stimulators and co-mitogens in dendritic cell-T cell interaction‘, Advances in experimental medicine and biology, 329,():53-8
Dabrowski M, Ibrahim MA, Chain BM, Katz DR (1993) ‘The role of dendritic cells as co-stimulators in tolerance induction‘, Advances in experimental medicine and biology, 329,():105-10
Knight B, Katz DR, Isenberg DA, Ibrahim MA, Le Page S, Hutchings P, Schwartz RS, Cooke A (1992) ‘Induction of adjuvant arthritis in mice‘, Clinical and experimental immunology, 90,(3):459-65
Ellis JS, Chain BM, Cooke A, Ibrahim MA, Katz DR (1992) ‘Adjuvant composition determines the induction of type II collagen-induced arthritis‘, Scandinavian journal of immunology, 36,(1):49-56
Ibrahim MA, Ellis JS, Chain BM, Katz DR (1992) ‘Sensitization of allo-specific T lymphocytes in vivo: role of antigen-presenting cells‘, Immunobiology, 186,(5):362-77
Ellis J, Chain BM, Davies DH, Ibrahim MA, Katz DR, Kaye PM, Lightstone E (1991) ‘Antigen presentation by dendritic cells provides optimal stimulation for the production of interleukin (IL) 2, IL 4 and interferon-gamma by allogeneic T cells‘, European journal of immunology, 21,(11):2803-9
Ibrahim MA, Coode WK, Takei F, Ellis JS, Chain BM, Katz DR (1991) ‘Chemically modified antigen-presenting cells induce T lymphocyte allospecific hyporesponsiveness‘, Journal of immunology (Baltimore, Md. : 1950), 147,(12):4086-93
Ibrahim MA, Lamb FI, Colston MJ (1990) ‘Analysis of variation in batches of armadillo-derived Mycobacterium leprae by immunoblotting‘, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 58,(1):73-7